Massachusetts General Hospital (MGH) recently achieved a groundbreaking milestone by successfully performing the world’s first transplant of a genetically-edited pig kidney into a 62-year-old man with end-stage kidney disease.
The surgery, conducted by surgeons from the Mass General Transplant Center, lasted four hours and took place on March 16. This achievement is a significant advancement in providing more accessible organs for patients in need.
The pig kidney used in the transplant was genetically edited to remove harmful pig genes and incorporate certain human genes to enhance compatibility with humans. This breakthrough comes at a critical time when there is a growing shortage of human organ donors.
In the U.S. alone, over 100,000 people are on the waiting list for organ transplants, with 17 individuals dying each day while waiting for an organ. Kidneys are particularly in high demand, with end-stage kidney disease rates projected to rise significantly by 2030.
The recipient of the pig kidney, Richard Slayman, who also suffers from Type 2 diabetes and hypertension, had previously received a human kidney transplant in 2018. However, when that kidney began to fail, he resumed dialysis. The successful pig kidney transplant not only offers hope to Mr. Slayman but also to thousands of others awaiting life-saving transplants.
Dr. Winfred Williams, Mr. Slayman’s nephrologist, highlighted the potential of this breakthrough in addressing health disparities, particularly among ethnic minorities who face higher rates of kidney disease.
This pioneering surgery, part of the field of xenotransplantation, marks a significant step forward in organ transplantation, with Mr. Slayman being the first living person to receive a pig kidney. The hospital commended Mr. Slayman’s courage and willingness to explore new medical frontiers, emphasizing the transformative impact of this achievement on patients with end-stage renal disease.
