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FG: Madagascar’s “COVID Organics” ineffective against COVID-19

The National Institute of Pharmaceutical Research and Development (NIPRD) has announced that its analysis and finding on the popular Madagascar herbal formulation, “COVID Organics”,  has established that the drug may be ineffective in the cure of the ravaging coronavirus, contrary to popular claims.

Branded as herbal tea by its promoters, the COVID Organics formulation was launched on April 20, with its main ingredient being sweet wormwood (Artemisia annua), a plant of Asian origin from where the antimalarial drug, artemisinin, was developed. Some cartons of the COVID Organics arrived in Nigeria last May.

President Muhammadu Buhari on receiving the formulation from Umaro Sissoco Embalo, his Guinea Bissau counterpart, directed that the potency of the drug be verified by the appropriate agencies of government before they would be sanctioned for public use.

“We have our institutions, systems and processes in the country. Any such formulations should be sent to them for verification. I will not put it to use without the endorsement of our institutions,” Buhari had said.

On Sunday, the NIPRD made public, its findings on the potency of the organic formulation and reported that it may not be as potent as earlier advertised by the authorities in Madagascar.

“Safety studies show that COVID ORGANICS (CVO) products do not alter the normal physiology of the animals,” NIPRD announced.

“CVO caused a significant decrease in the platelet counts although the values are within the physiological range for Wistar rats.

“The increase in alkaline phosphatase observed in the CVO female group may indicate a cause of concern although the values are within the physiological ranges for Wistar rats and this was not observed in the organs.

“On the whole CVO can be considered safe based on the model used which did not cover other routes of administration, effects of long-term use, or organ histological evaluation of the test systems.

“CVO reduced cough frequency with the maximum dose tested producing an effect equivalent to that produced by the centrally acting cough-suppressant, dihydrocodeine.

“To further characterise this product based on its effect on the respiratory tract, it will be important to investigate its effect on tracheal mucus expectoration.

“While CVO dose-dependently reduced general febrile response, the effect was not sustained and was less than for indomethacin.”

The director-general of NIPRD, Obi Adigwe, accused the authorities in Madagascar of withholding valuable information.

“Well, I cannot tell you what they have done. I can only tell you what we have done here,” he told reporters.

“The analysis we gave in our report is more detailed than anything that had come from their country. They are hiding the analysis of their own product. If you go online, you cannot get the level of analysis that we gave.”

The World Health Organisation (WHO) had initially warned countries against adopting the product because “it has not been taken through tests to see its efficacy”.

“We are concerned that touting this product as a preventive measure might then make people feel safe,” Matshidiso Moeti, WHO’s head in Africa, had said.

The position of the NIPRD is likely to raise further controversy as the race to find a cure (or a vaccine) for the pandemic continues.